PST2744 (hydrochloride)

Name	Istaroxime (hydrochloride)
Synonyms	PST2774 PST-2774 PST2744 (hydrochloride) PST 2744 (hydrochloride) PST-2744 (hydrochloride) IstaroxiMe (hydrochloride) Istaroxime (hydrochloride) Istaroxime hydrochloride(PST2744) (5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride
CAS	374559-48-5

Molecular Formula	C21H33ClN2O3
Molar Mass	396.95132
Solubility	DMSO: ≥ 45 mg/mL
Storage Condition	-20℃
In vitro study	Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
In vivo study	Istaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg.

Last Update：2024-01-02 23:10:35

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CAS: 374559-48-5
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PST2744 (hydrochloride)

PST2744 (hydrochloride) Request for Quotation